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Publication Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms(Frontiers Media SA, 2024-07-04)Language disturbances are a core feature of schizophrenia, often studied as a formal thought disorder. The neurobiology of language in schizophrenia has been addressed within the same framework, that language and thought are equivalents considering symptoms and not signs. This review aims to systematically examine published peer-reviewed studies that employed neuroimaging techniques to investigate aberrant brain-language networks in individuals with schizophrenia in relation to linguistic signs. - Some of the metrics are blocked by yourconsent settings
Publication A systematic methodology for port-Hamiltonian modeling of multidimensional flexible linear mechanical systems(Elsevier BV, 2024-10)This article introduces a novel systematic methodology for modeling a class of multidimensional linear mechanical systems that directly allows to obtain their infinite-dimensional port-Hamiltonian representation. While the approach is tailored to systems governed by specific kinematic assumptions, it encompasses a wide range of models found in current literature, including ℓ-dimensional elasticity models (where ℓ = 1, 2, 3), vibrating strings, torsion in circular bars, classical beam and plate models, among others. The methodology involves formulating the displacement field using primary generalized coordinates via a linear algebraic relation. The non-zero components of the strain tensor are then calculated and expressed using secondary generalized coordinates, enabling the characterization of the skew-adjoint differential operator associated with the port-Hamiltonian representation. By applying Hamilton's principle and employing a specially developed integration by parts formula for the considered class of differential operators, the port-Hamiltonian model is directly obtained, along with the definition of boundary inputs and outputs. To illustrate the methodology, the plate modeling process based on Reddy's third-order shear deformation theory is presented as an example. To the best of our knowledge, this is the first time that a port-Hamiltonian representation of this system is presented in the literature. - Some of the metrics are blocked by yourconsent settings
Publication Data-driven physics-guided metamodels in structural dynamics: comparative assessment(NDT.net GmbH & Co. KG, 2026-02)This study presents a benchmark of two physics-guided neural surrogates – PhyCNN and multi–LSTM – across three single-degree-of-freedom system scenarios of increasing nonlinearity: (I) a Duffing oscillator; (II) a hysteretic Bouc–Wen system under band-limited noise; and (III) a hysteretic Bouc–Wen isolator representative of base-isolated buildings subjected to long duration Chilean earthquakes. Physics-guided LSTMs achieve the lowest errors in displacement and velocity and better reproduce hysteretic geometry; CNNs yield tighter, more stable errors when the normalized internal force is predicted directly. Reconstructing force from LSTM velocity closes much of the gap but remains fragile in long, strongly nonlinear records due to residual-drift accumulation. Simple training discipline—input/target normalization, validation-driven early stopping and scheduling, and light force regularization—substantially improves robustness. - Some of the metrics are blocked by yourconsent settings
Publication Multiple Local and Global Bifurcations and Their Role in Quorum Sensing Dynamics(2025-01-14)Quorum sensing governs bacterial communication, playing a crucial role in regulating population behaviour. We propose a mathematical model that uncovers chaotic dynamics within quorum sensing networks, highlighting challenges to predictability. The model explores interactions between autoinducers and two bacterial subtypes, revealing oscillatory dynamics in both a constant autoinducer sub-model and the full three-component model. In the latter case, we find that the complicated dynamics can be explained by the presence of homoclinic Shilnikov bifurcations. We employed a combination of normal form analysis and numerical continuation methods to analyse the system. - Some of the metrics are blocked by yourconsent settings
Publication A synthetic approach towards drug modification: 2-hydroxy-1-naphthaldehyde based imine-zwitterion preparation, single-crystal study, Hirshfeld surface analysis, and computational investigation(Royal Society of Chemistry (RSC), 2024)The present study focuses on the modification of primary amine–functionalized drugs, namely pyrimethamine and 4-amino-N-(2,3-dihydrothiazol-2-yl)benzenesulfonamide, through a condensation reaction with 2-hydroxy-1-naphthaldehyde in methanol, yielding two new organic zwitterionic compounds: (E)-1-(((4-(N-(2,3-dihydrothiazol-2-yl)sulfamoyl)phenyl)iminio)methyl)naphthalen-2-olate (DSPIN) and (E)-1-(((4-amino-5-(4-chlorophenyl)-6-ethylpyrimidin-2-yl)iminio)methyl)naphthalen-2-olate (ACPIN). The crystal structures of both compounds were confirmed as imine-based zwitterionic products by single-crystal X-ray diffraction (SC-XRD), revealing stabilization through various noncovalent interactions. Supramolecular assembly was investigated using Hirshfeld surface analysis, while void analysis was employed to predict the mechanical response of the crystals. Density Functional Theory (DFT) calculations showed good agreement with experimental structural parameters. Frontier molecular orbital (FMO) analysis indicated that the HOMO–LUMO gap of DSPIN is 0.15 eV smaller than that of ACPIN, attributed to HOMO destabilization and LUMO stabilization in DSPIN. Charge distribution analysis suggested the presence of intramolecular hydrogen bonding, as well as intermolecular hydrogen bonds, dipole–dipole, and dispersion interactions.Scopus© Citations 18
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Publication The experimental facility for the Search for Hidden Particles at the CERN SPS(2019-03-25)The Search for Hidden Particles (SHiP) Collaboration has shown that the CERN SPS accelerator with its 400 GeV c proton beam offers a unique opportunity to explore the Hidden Sector [1–3]. The proposed experiment is an intensity frontier experiment which is capable of searching for hidden particles through both visible decays and through scattering signatures from recoil of electrons or nuclei. The high-intensity experimental facility developed by the SHiP Collaboration is based on a number of key features and developments which provide the possibility of probing a large part of the parameter space for a wide range of models with light long-lived superweakly interacting particles with masses up to O¹10º GeV c2 in an environment of extremely clean background conditions. This paper describes the proposal for the experimental facility together with the most important feasibility studies. The paper focuses on the challenging new ideas behind the beam extraction and beam delivery, the proton beam dump, and the suppression of beam-induced background. - Some of the metrics are blocked by yourconsent settings
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Publication Audit and diagnosis in asset management and maintenance applied in the electrical industry(2021-05-01)In the framework of asset management, the effectiveness of an integrated process that manages reliability and maintenance should be adequately and timely evaluated based on a thorough analysis of a series of contributing factors, which should respond entirely to the result of maintenance activities on the performance of assets that make up the production process. According to the above, then arises the motivation for the design and application of tools to determine the effectiveness of such activities in asset management, understanding the latter as a holistic process that involves a diversity of functions and areas within an organization - Some of the metrics are blocked by yourconsent settings
Publication A Lyapunov Approach to Robust Regulation of Distributed Port-Hamiltonian Systems(2021-12-01)This article studies robust output tracking and disturbance rejection for boundary-controlled infinite-dimensional Port– Hamiltonian systems including second-order models such as the Euler–Bernoulli beam equation. The control design is achieved using the internal model principle and the stability analysis using a Lyapunov approach. Contrary to existing works on the same topic, no assumption is made on the external well-posedness of the considered class of PDEs. The results are applied to robust tracking of a piezo actuated tube used in atomic force imaging. - Some of the metrics are blocked by yourconsent settings
Publication Understanding the synergetic effects of mechanical milling and hot pressing on bimodal microstructure and tribo-mechanical behavior in porous Ti structures(2023-11-01)The utilization of porous biomedical implants featuring a bimodal microstructure has garnered substantial interest within the scientific community. This study delves into the intricate interplay between processing parameters, microstructural attributes, and the tribo-mechanical performance of titanium grade 4, showcasing its potential to serve as implants to address compromised cortical bone tissue. The investigation meticulously examines the impact of milling duration (10 and 20 h), proportion of milled powder (50 and 75 wt%), and the volume fraction of space-holding agents (40–60 vol% NaCl) on the resulting characteristics of the bimodal microstructure, which plays a crucial role in achieving optimal biomechanical equilibrium. The Vickers microhardness, conventional and instrumented (P-h curves), and the wear behavior (ball-on disk) are discussed in terms of bimodal microstructure distribution, particle size and porosity level inherent to the fabrication conditions (mechanical milling + space-holder + hot-pressing). In general terms, milling time and milled powder fraction were the most influent parameters on the final properties of the materials. With the processing route used, the achieved microhardness values and wear behavior are comparable with those obtained by means of surface modifications or alloys. The Young's moduli obtained were in the range of 30–50 GPa, which could help to reduce the shielding phenomenon, while presenting a good mechanical resistance and wear behavior. In light of these findings, the fabricated specimen, composed of 75 wt% milled powder subjected to a 10-h milling duration, supplemented by a 60 vol% fraction of NaCl, emerges as a prime candidate manifesting superior biomechanical equilibrium. This judicious configuration exhibits a promising trajectory for its application in bone replacement endeavors.
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