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High-momentum configurations of nucleon pairs at short-distance are probed using measurements of the C-12(e, e p) and C-12(e, e pN) reactions (where N is either n or p), at high-Q(2) and x(B) > 1.1. The data span a missing-momentum range of 300-1000 MeV/c

Esta tesis examina la generación procedural de contenido en videojuegos, enfocándose en la creación de niveles y mazmorras. Primero, se analizan las técnicas generales de generación procedural, seguidas de un estudio más detallado sobre la generación de niveles. El trabajo principal se centra en un Algoritmo Evolutivo de 2 Pasos (2-Step EA) para generar mazmorras con misiones de llaves y barreras. La primera fase del algoritmo configura el diseño básico de la mazmorra, y la segunda fase asigna llaves y barreras estratégicamente. Los resultados muestran que el algoritmo propuesto es efectivo en producir mazmorras de alta calidad y eficientes computacionalmente. Este enfoque ofrece una metodología sólida para la generación procedural de contenido dinámico.

We have conducted an entropy analysis in Alaska, a seismic-rich region in a subduction zone that exhibits a nontrivial behavior: the subduction arc alters the seismic activity from the eastern zone to the western zone, demonstrating a decrease in activity along the subduction. We analyze this zone through the Tsallis entropy and the mutability (or dynamic entropy) for the first time. Considering 13 870 seismic events after appropriate filtering, we analyzed a data set for the selected Alaska zone between 2000 and 2023. We have found agreement between the results for the two entropies. We have followed the value of the q parameter of the Tsallis entropy (Sq) finding values between 1.70 and 1.85, in concordance with values found in other seismic regions of the planet. The values of Sq decrease slightly over time but show a broad increase before the major earthquakes. Just opposite to Tsallis entropy, mutability shows a tendency to decrease prior to the major earthquakes. We used the simpler mutability method to further analyze this zone upon dividing the region into four subzones. The results show how mutability can identify the seismic activity in each zone. This study shows how an entropy approach can shed light on understanding the seismicity in subduction zones.

We have conducted an entropy analysis in Alaska, a seismic-rich region in a subduction zone that exhibits a nontrivial behavior: the subduction arc alters the seismic activity from the eastern zone to the western zone, demonstrating a decrease in activity

The transition from planar to three-dimensional (3D) magnetic nanostructures represents a significant advancement in both fundamental research and practical applications, offering vast potential for next-generation technologies like ultrahigh-density stor

Next generation wireless and mobile networks will utilize millimeter-wave (mmWave) communication to achieve significantly increased data rates. However, since mmWave radio signals experience high path loss, the operation of mmWave networks will require accurate channel models designed for specific deployment sites. In this paper, we focus on the deployment area of the PAWR COSMOS testbed [1, 2] in New York City and report extensive 28 GHz channel measurements. These include over 24 million power measurements collected from over 1,500 links on 13 sidewalks in 3 different sites and in different settings during March–June, 2019. Using these measurements, we study the effects of the setup and environments (e.g., transmitter height and seasonal effects). We then discuss the obtained path gain values and their fitted lines, and the resulting effective azimuth beamforming gain. Based on these results, we also study the link SNR values that can be supported on individual sidewalks and the corresponding theoretically achievable data rates. We believe that the results can inform the COSMOS testbed deployment process and provide a benchmark for other deployment efforts in dense urban areas.

Malaria is an infectious disease caused by Plasmodium spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molecular similarity index analysis (CoMSIA), and a 2D-QSAR model, using a database of 349 compounds with activity against the P. falciparum 3D7 strain. The models were validated internally and externally, complying with all metrics (q2 > 0.5, r2test > 0.6, r2m > 0.5, etc.). The final models have shown the following statistical values: r2test CoMFA = 0.878, r2test CoMSIA = 0.876, and r2test 2D-QSAR = 0.845. The models were experimentally tested through the synthesis and biological evaluation of ten quinoline derivatives against P. falciparum 3D7. The CoMSIA and 2D-QSAR models outperformed CoMFA in terms of better predictive capacity (MAE = 0.7006, 0.4849, and 1.2803, respectively). The physicochemical and pharmacokinetic properties of three selected quinoline derivatives were similar to chloroquine. Finally, the compounds showed low cytotoxicity (IC50 > 100 µM) on human HepG2 cells. These results suggest that the QSAR models accurately predict the toxicological profile, correlating well with experimental in vivo data.

Malaria is an infectious disease caused by Plasmodium spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molecular

Electrical trees are one of the main mechanisms of degradation in solid polymeric insulation leading to the failure of high voltage equipment. They are interconnected networks of hollow tubules typically characterized from two-dimensional (2D) projections of their physical manifestation. It is shown that complete characterization requires a three-dimensional (3D) imaging technique such as X-ray computed tomography (XCT). We present a comprehensive set of parameters, quantitatively characterizing two types of tree topology, conventionally known as bush- and branchtype. Fractal dimensions are determined from 3D models and from 2D projections, and a simple quantitative relationship is established between the two for all but dense bush trees. Parameters such as number of nodes, segment length, tortuosity and branch angle are determined from tree skeletons. The parameters most strongly indicative of the differences in the structure are the number of branches, individual channel size, channel tortuosity, nodes per unit length and fractal dimension. Studying two stages of a bush tree's development showed that channels grew in width, while macroscopic parameters such as the fractal dimension and tortuosity were unchanged. These parameters provide a basis for tree growth models, and can shed light on growth mechanisms.

Los sistemas de sostenimiento con pilotes anclados discontinuos se utilizan con frecuencia en excavaciones profundas temporales en Santiago de Chile, debido a las condiciones geológicas caracterizadas por suelos gravo-arenosos rígidos y un nivel freático profundo. Esta investigación presenta un estudio integral que incluye el desarrollo de un modelo 3D para simular este tipo de excavaciones con pilotes anclados discontinuos. Se emplea el modelo constitutivo HS-Small para replicar con precisión las propiedades del suelo gravoso de Santiago, utilizando parámetros calibrados en base a ensayos geofísicos y de laboratorio de investigaciones previas. El objetivo principal del estudio es realizar un análisis dinámico utilizando dos ondas tipo Ricker y ondas sísmicas aplicadas en dos direcciones. Este análisis busca simular eventos sísmicos reales y evaluar la integridad estructural de los sistemas de sostenimiento bajo tales condiciones. Se emplean técnicas computacionales avanzadas para modelar con precisión el comportamiento de estos sistemas. Además, los resultados de los análisis dinámicos se comparan con las normativas chilenas para evaluar el desempeño estructural. Esta comparación es clave para determinar si las normas son conservadoras y si los sistemas cumplen con los criterios de seguridad y rendimiento requeridos. Los resultados obtenidos de los análisis dinámicos y la comparación con las normativas chilenas aportan información valiosa sobre el comportamiento y la eficacia de los sistemas de pilotes anclados discontinuos bajo cargas dinámicas. Se observa que los pilotes ubicados en esquinas experimentan menores desplazamientos y fuerzas internas, pero mayores empujes de suelo. Además, en algunos escenarios, las presiones del suelo inducidas dinámicamente superan las calculadas por la normativa, lo que sugiere oportunidades de mejora en las prácticas de diseño.

Abstract During a visual search through the Kepler main-field light curves, we have discovered a cataclysmic variable (CV) that experienced only a single 4-d long outburst over four years, rising to three times the quiescent flux. During the four years of non-outburst data the Kepler photometry of KIC 5608384 exhibits ellipsoidal light variations (‘ELVs’) with a ∼12 per cent amplitude and period of 8.7 h. Follow-up ground-based spectral observations have yielded a high-quality radial velocity curve and the associated mass function. Additionally, H α emission lines were present in the spectra even though these were taken while the source was presumably in quiescence. These emission lines are at least partially eclipsed by the companion K star. We utilize the available constraints of the mass function, the ELV amplitude, Roche lobe filling condition, and inferred radius of the K star to derive the system masses and orbital inclination angle: $M_{\rm wd} \simeq 0.46 \pm 0.02 \, \mathrm{M}_\odot$, $M_{\rm K} \simeq 0.41 \pm 0.03 \, \mathrm{M}_\odot$, and i ≳ 70°. The value of Mwd is the lowest reported for any accreting WD in a CV. We have also run binary evolution models using mesa to infer the most likely parameters of the pre-cataclysmic binary. Using the mass-transfer rates from the model evolution tracks we conclude that although the rates are close to the critical value for accretion disc stability, we expect KIC 5608384 to exhibit dwarf nova outbursts. We also conclude that the accreting white dwarf most likely descended from a hot subdwarf and, most notably, that this binary is one of the first bona fide examples of a progenitor of AM CVn binaries to have evolved through the CV channel.

This paper addresses one of the main tasks in transparent static elastic optical networks (EONs), known as the routing, modulation level, and spectrum assignment (RMLSA) problem. We present, for the first time, a two-stage RMLSA solution, focusing on redu

In this paper, we develop a filtering algorithm for Wiener systems written in state-space form which considers correlated noise sources. The output non-linearity is approximated by using a piece-wise linear function. The probability function of the output signal conditioned to the system state is written as a Gaussian mixture distribution. A Gaussian sum filter algorithm to obtain the a posteriori probability density function of the state given the current and past output is developed. The associated statistics of the system state are obtained. The benefits of our proposal are illustrated via numerical simulations.

The frequent occurrence of floods during the rainy season is one of the threats in rainfed river basins, especially in river basins of India. This study implemented a Bayesian hierarchical model combination (BHMC) framework to generate skillful and reliab

A novel Bayesian Hierarchical Network Model (BHNM) for ensemble forecasts of daily streamflow is presented that uses the spatial dependence induced by the river network topology and hydrometeorological variables from the upstream contributing area between

Progress in R&D on memristors and memristive devices can be boosted by practical and comprehensive device models for circuit simulations. In this context, this paper constitutes a guide for the modular development of behavioral models of memristive device

This work presents a novel dc-dc bidirectional buck-boost converter between a battery pack and the inverter to regulate the dc-bus in an electric vehicle (EV) powertrain. The converter is based on the versatile buck-boost converter, which has shown an exc

Esta tesis aborda el problema conjunto de localización e inventario para el diseño de una red de distribución de dos niveles bajo demanda estocástica, en la que los centros de distribución candidatos operan con una política de revisión continua (r, Q), tiempos de entrega determinísticos y full backorders. El problema integra simultáneamente decisiones de apertura de centros de distribución, asignación de retail y definición de los parámetros óptimos de la política de inventario, incorporando además restricciones de nivel de servicio basadas en fill-rate en cada instalación. Con el fin de representar adecuadamente estas interacciones, se formula un modelo no convexo de programación no lineal entera mixta (MINLP) que describe explícitamente el inventario disponible, los pedidos pendientes esperados y las restricciones de nivel de servicio bajo demanda normalmente distribuida. Posteriormente, se desarrolla una reformulación convexa equivalente mediante la introducción de variables auxiliares para los términos de agregación de demanda, obteniéndose un problema convexo de programación no lineal entera mixta con restricciones de conos de segundo orden. Sobre esta base, se propone un enfoque de resolución que combina Outer Approximation y Branch & Cut para resolver el problema de manera eficiente. El enfoque propuesto permite estudiar el desempeño de ambos métodos comparando sus tiempos computacionales y gap de optimalidad para ver qué método resulta más conveniente para este tipo de problemas.

Since the start of the pandemic caused by the novel coronavirus, COVID-19, more than 106 million people have been infected and global deaths have surpassed 2.4 million. In Chile, the government restricted the activities and movement of people, organizatio

The effects of climate change are growing more and more evident, and this is caused by the increase in CO2 emissions. Fossil fuel exhaustion and the need for electricity in remote areas have encouraged researchers to advance and develop the renewable ener