Thesis: Adsorción de triptófano en nanomateriales a base de carbono
| datacite.subject.fos | Natural sciences::Physical sciences | |
| datacite.subject.fos | Engineering and technology | |
| datacite.subject.fos | Medical and Health sciences | |
| datacite.subject.fos | Engineering and technology::Materials engineering | |
| datacite.subject.fos | Medical and Health sciences::Medical biotechnology | |
| dc.contributor.department | Departamento de Física | |
| dc.contributor.guia | Del Campo Sfeir, Valeria Isabel | |
| dc.coverage.spatial | Campus Casa Central Valparaíso | |
| dc.creator | Flores Bahamóndez, Sofia Antonia | |
| dc.date.accessioned | 2026-01-15T14:51:27Z | |
| dc.date.available | 2026-01-15T14:51:27Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | La nanomedicina ha hecho aportes significativos para la salud de las personas, desarrollando implantes, terapias, medicamentos y reparación de tejidos, entre otros. Para diseñar materiales implantables que imiten las funciones biológicas requeridas, es importante comprender la respuesta del cuerpo humano a estos materiales. Por lo tanto, es fundamental comprender la interacción entre nanomateriales y biomoléculas como los aminoácidos, unidad principal de las proteínas. En este trabajo estudiamos experimentalmente la interacción de nanomateriales a base de carbono: grafeno y óxido de grafeno, con distintos tipos de triptófano. La síntesis de nanomateriales fue llevada a cabo mediante la técnica de PECVD (Plasma Enhanced Chemical Vapor Deposition) y, utilizando una técnica libre de polímeros, transferimos nanomateriales de áreas grandes (~2,8 cm²) a distintos tipos de sustratos. Estudiamos la estructura de los nanomateriales y de los distintos tipos de triptófano mediante espectroscopía Raman y microscopía óptica, y analizamos la naturaleza de su interacción mediante mediciones de absorbancia ultravioleta. Los resultados muestran que, en los casos en que el triptófano se adsorbe en el nanomaterial, el cambio de concentración no depende de la concentración inicial de la solución de triptófano ni del área del nanomaterial. A partir de mediciones AFM (Atomic Force Microscopy) inferimos que el triptófano se adsorbe en la superficie del nanomaterial en aglomeraciones, sugiriendo que las isotermas de adsorción obtenidas en cada experimento podrían ser ajustadas con modelos de adsorción en multicapas como el modelo BET (Brunauer-Emmett-Teller). En esta tesis también presentamos el trabajo realizado durante una pasantía en el Institut National de l'Énergie Solaire (Francia). A través de la técnica de elipsometría espectroscópica, estudiamos los índices ópticos del grafeno, obteniendo valores menores a los reportados en la literatura. | es |
| dc.description.abstract | Nanomedicine has made significant contributions to human health, developing implants, therapies, drugs and tissue repair, among others. In order to design implantable materials that mimic the required biological functions, it is important to understand the response of the human body to these materials. To do so, it is essential to understand the interaction between the surfaces of these materials and biomolecules, such as amino acids, the main unit of proteins. In this work, we experimentally studied the interaction of carbon-based nanomaterials: graphene and graphene oxide, with different types of tryptophan. The synthesis of nanomaterials was carried out using the PECVD (Plasma Enhanced Chemical Vapor Deposition) technique and by means of a polymer-free technique, we transferred large-area nanomaterials (~2.8 cm²) to different types of substrates. Raman spectroscopy and optical microscopy were used to study the structure of nanomaterials and different types of tryptophan. We have analyzed the nature of the interaction by absorbance measurements, and we observed that in cases where tryptophan is adsorbed on the nanomaterial, the concentration change does not depend on the initial concentration of the tryptophan solution or on the surface area of the nanomaterial. From AFM (Atomic Force Microscopy) measurements we infer that tryptophan is adsorbed on the surface of the nanomaterial in agglomerations, suggesting that the adsorption isotherms obtained in each experiment could be fitted with multilayer adsorption models such as the BET (Brunauer-Emmett-Teller) model.In this thesis we also present the work carried out during an internship at the Institut National de l'Énergie Solaire (France). By means of the spectroscopic ellipsometry technique, we studied the optical indices of graphene, obtaining lower values than those reported in the literature. | en_US |
| dc.description.degree | Magíster en Ciencias mención Física | |
| dc.description.sponsorship | ANID-ECOS210038 #C21E08 “Graphene as transparent current spreading electrode in silicon heterojunction solar cells” | |
| dc.description.sponsorship | “Millennium Nucleus in NanoBioPhysics” proyecto ANID - Millennium Science Initiative Program NNBP # NCN2021_021 | |
| dc.description.sponsorship | “Glass nanopatterning for self cleaning photovoltaic modules” proyecto Fondecyt # 1210490 | |
| dc.description.sponsorship | “Solar Energy Research Center” proyecto ANID/FONDAP # 1523A0006. | |
| dc.driver | info:eu-repo/semantics/masterThesis | |
| dc.format.extent | 89 páginas | |
| dc.identifier.doi | 10.71959/2sfp-c022 | |
| dc.identifier.uri | https://cris.usm.cl/handle/123456789/4259 | |
| dc.identifier.uri | https://doi.org/10.71959/2sfp-c022 | |
| dc.language.iso | es | |
| dc.publisher | Universidad Técnica Federico Santa María | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | adsorción | |
| dc.subject | aminoácido | |
| dc.subject | triptófano | |
| dc.subject | grafeno | |
| dc.subject | óxido de grafeno | |
| dc.subject.ods | 3 Salud y bienestar | |
| dc.subject.ods | 9 Industria, innovación e infraestructura | |
| dc.subject.ods | 12 Producción y consumo responsables | |
| dc.title | Adsorción de triptófano en nanomateriales a base de carbono | |
| dc.type | http://purl.org/coar/resource_type/c_46ec | |
| dspace.entity.type | Tesis |
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